RCU Detox targets what's known as cell-free DNA (cfDNA). This is DNA released, for instance, when cells die, and billions of cells die every day. Normally, the body can break down cfDNA itself, which occurs when immune cells release an enzyme called DNase-1. During inflammation, however, this ability can be impaired, either because more cfDNA is produced than can be broken down or because the ability to break it down is diminished. In certain conditions, it has been shown that the enzyme may be mutated, meaning it doesn't function normally. cfDNA is classified as a damage-associated molecular pattern and activates immune cells via specific DNA sensors that detect both endogenous cfDNA and foreign DNA from bacteria and viruses. cfDNA doesn't just come from regular cells that die regularly in the body but can also come from immune cells, such as what are called neutrophil extracellular traps. This is a good example of how an immune cell is activated, releases cfDNA, and drives ongoing inflammation by activating other cells, creating an inflammatory loop. When cfDNA is released, the presentation of what are called self- or autoantigens also increases, thereby reducing self-tolerance where the immune system doesn't differentiate between self and foreign. This is the basis for the development of autoimmunity.

RCU Detox is based on resveratrol found in grapes and the nutrient copper. In a certain amount and proportion, research has shown that this helps break down cfDNA about as effectively as DNase-1. The amount of copper per daily dose is 0.00056mg, so it's very small amounts. If taken in excess, the effectiveness decreases. Therefore, always follow the dosage indicated on the packaging. RCU DETOX can be used periodically or continuously. Studies on mice only show benefits with long-term use to dampen metabolic and mitochondrial dysfunction. Always follow the dosage instructions on the packaging.

This is a dietary supplement and should not replace a varied diet. The product is not recommended for pregnant and breastfeeding women to err on the side of caution. Store in a dry place and out of reach of children.

Further reading:

1. Raghuram GV, Tripathy BK, Avadhani K, et al. Cell-free chromatin particles released from dying cells inflict mitochondrial damage and ROS production in living cells. Cell Death Discov. 2024;10(1):30. Published 2024 Jan 15. doi:10.1038/s41420-023-01728-z

  Shabrish S, Pal K, Khare NK, et al. Cell-free chromatin particles released from dying cancer cells activate immune checkpoints in human lymphocytes: implications for cancer therapy. Front Immunol. 2024;14:1331491. Published 2024 Jan 11. doi:10.3389/fimmu.2023.1331491

3. Pilankar A, Singhavi H, Raghuram GV, et al. A pro-oxidant combination of resveratrol and copper down-regulates hallmarks of cancer and immune checkpoints in patients with advanced oral cancer: Results of an exploratory study (RESCU 004). Front Oncol. 2022;12:1000957. Published 2022 Sep 16. doi:10.3389/fonc.2022.1000957

4. Chaudhary S, Mittra I. Cell-free chromatin: A newly described mediator of systemic inflammation. J Biosci. 2019;44(2):32.

5. Mittra I, Khare NK, Raghuram GV, et al. Circulating nucleic acids damage DNA of healthy cells by integrating into their genomes.
J Biosci. 2015;40(1):91-111. doi:10.1007/s12038-015-9508-6

6. Mittra I, Pal K, Pancholi N, et al. Prevention of chemotherapy toxicity by agents that neutralize or degrade cell-free chromatin. Ann Oncol. 2017;28(9):2119-2127. doi:10.1093/annonc/mdx318

7.  Hashimoto T, Yoshida K, Hashiramoto A, Matsui K. Cell-Free DNA in Rheumatoid Arthritis. Int J Mol Sci. 2021;22(16):8941. Published 2021 Aug 19. doi:10.3390/ijms22168941

8.  Peng Y, Wu Y, Chen S, et al. Circulating cell-free DNA correlate to disease activity and treatment response of patients with radiographic axial spondyloarthritis. Sci Rep. 2024;14(1):178. Published 2024 Jan 2. doi:10.1038/s41598-023-50543-0

9.  Duvvuri B, Lood C. Cell-Free DNA as a Biomarker in Autoimmune Rheumatic Diseases. Front Immunol. 2019;10:502. Published 2019 Mar 19. doi:10.3389/fimmu.2019.00502

10.  Mondelo-Macía P, Castro-Santos P, Castillo-García A, Muinelo-Romay L, Diaz-Peña R. Circulating Free DNA and Its Emerging Role in Autoimmune Diseases. J Pers Med. 2021;11(2):151. Published 2021 Feb 20. doi:10.3390/jpm11020151