Health begins in the gut, and that's where Symbios starts its journey in the body, but it's far from being the final destination. This product has a very broad mechanism of action, and when you start with the Lemon Protocol™, it's good to include Symbios as it interacts very well with RCU Detox and Akoge. Once you have achieved your desired outcome, you can either continue or reduce the dose, or alternatively, use Symbios periodically a few times a year.

The purpose of Symbios broadly aims to promote and restore balance in the intestines by primarily regulating NLRP6/IL-18/antimicrobial peptides (AMP). Defective regulation in these areas promotes dysbiosis, leaky gut, where, for example, bacterial toxin LPS, TLR4 and TLR9 agonists, histamine, and other substances can enter circulation and drive systemic inflammation. However, as mentioned, Symbios only begins its journey in the gut. The active ingredients contribute to an increase in halomines that inhibit NF-kB (master regulatory transcription factor for inflammation) and activate NRF2, which regulates intracellular antioxidants (catalase, superoxide dismutase, glutathione), and they also inhibit glycolysis. Glycolysis is a metabolic pathway that activated cells use to metabolize sugar. By inhibiting it, significant obstacles are placed in the way of inflammation.

The product is based on a combination of the sugar D-mannose and the amino acid taurine. We always adjust the dosage to achieve the best possible effect, so the dosage indicated on the packaging should not be exceeded.

This is a dietary supplement and should not replace a varied diet. The product is not recommended for pregnant and breastfeeding women to err on the side of caution. Store in a dry place and out of reach of children.

Futher reading:
1. Xiao P, Hu Z, Lang J, et al. Mannose metabolism normalizes gut homeostasis by blocking the TNF-α-mediated proinflammatory circuit. Cell Mol Immunol. 2023;20(2):119-130. doi:10.1038/s41423-022-00955-

2. Zhang H, Zhao X, Gao Y, et al. D-Mannose promotes recovery from experimental colitis by inducing AMPK phosphorylation to stimulate epithelial repair.
Food Funct. 2024;15(2):625-646. Published 2024 Jan 22. doi:10.1039/d3fo03146b

3. Dong L, Xie J, Wang Y, et al. Mannose ameliorates experimental colitis by protecting intestinal barrier integrity. Nat Commun. 2022;13(1):4804. Published 2022 Aug 16. doi:10.1038/s41467-022-32505-8

4. Wen C, Guo Q, Wang W, et al. Taurine Alleviates Intestinal Injury by Mediating Tight Junction Barriers in Diquat-Challenged Piglet Models. Front Physiol. 2020;11:449. Published 2020 May 28. doi:10.3389/fphys.2020.00449

5. Ahmadi S, Wang S, Nagpal R, et al. A human-origin probiotic cocktail ameliorates aging-related leaky gut and inflammation via modulating the microbiota/taurine/tight junction axis. JCI Insight. 2020;5(9):e132055. Published 2020 May 7. doi:10.1172/jci.insight.132055

6. Ma YD, Lv QF, Zhao DD, et al. Intervention Effect of Taurine on LPS-Induced Intestinal Mechanical Barrier Injury in Piglets. Adv Exp Med Biol. 2022;1370:73-80. doi:10.1007/978-3-030-93337-1_7

7. Qian W, Li M, Yu L, Tian F, Zhao J, Zhai Q. Effects of Taurine on Gut Microbiota Homeostasis: An Evaluation Based on Two Models of Gut Dysbiosis. Biomedicines. 2023;11(4):1048. Published 2023 Mar 29. doi:10.3390/biomedicines11041048

8. Wang H, Teng X, Abboud G, Li W, Ye S, Morel L. D-mannose ameliorates autoimmune phenotypes in mouse models of lupus. BMC Immunol. 2021;22(1):1. Published 2021 Jan 5. doi:10.1186/s12865-020-00392-7  

9. Wang J, Jalali Motlagh N, Wang C, et al. d-mannose suppresses oxidative response and blocks phagocytosis in experimental neuroinflammation. Proc Natl Acad Sci U S A. 2021;118(44):e2107663118. doi:10.1073/pnas.2107663118  

10. Zhou J, Lu Y, Wu W, Feng Y. Taurine promotes the production of CD4+CD25+FOXP3+ Treg cells through regulating IL-35/STAT1 pathway in a mouse allergic rhinitis model. Allergy Asthma Clin Immunol. 2021;17(1):59. Published 2021 Jun 19. doi:10.1186/s13223-021-00562-1

11.  Chen N, Zhao M, Guo Y, et al. D-mannose is a rapid inducer of ACSS2 to trigger rapid and long-lasting antidepressant responses through augmenting BDNF and TPH2 levels. Transl Psychiatry. 2023;13(1):338. Published 2023 Nov 1. doi:10.1038/s41398-023-02636-7

12. Maleki V, Mahdavi R, Hajizadeh-Sharafabad F, Alizadeh M. The effects of taurine supplementation on oxidative stress indices and inflammation biomarkers in patients with type 2 diabetes: a randomized, double-blind, placebo-controlled trial. Diabetol Metab Syndr. 2020;12:9. Published 2020 Jan 29. doi:10.1186/s13098-020-0518-7

13. Larabi AB, Masson HLP, Bäumler AJ. Bile acids as modulators of gut microbiota composition and function. Gut Microbes. 2023;15(1):2172671. doi:10.1080/19490976.2023.2172671

14. Qian W, Li M, Yu L, Tian F, Zhao J, Zhai Q. Effects of Taurine on Gut Microbiota Homeostasis: An Evaluation Based on Two Models of Gut Dysbiosis. Biomedicines. 2023;11(4):1048. Published 2023 Mar 29. doi:10.3390/biomedicines11041048

15. Lin EY, Lai HJ, Cheng YK, et al. Neutrophil Extracellular Traps Impair Intestinal Barrier Function during Experimental Colitis. Biomedicines. 2020;8(8):275. Published 2020 Aug 5. doi:10.3390/biomedicines8080275

16. Ma Y, Zhang Y, Li R, et al. Mechanism of taurine reducing inflammation and organ injury in sepsis mice. Cell Immunol. 2022;375:104503. doi:10.1016/j.cellimm.2022.104503

17.  Levy M, Thaiss CA, Zeevi D, et al. Microbiota-Modulated Metabolites Shape the Intestinal Microenvironment by Regulating NLRP6 Inflammasome Signaling. Cell. 2015;163(6):1428-1443. doi:10.1016/j.cell.2015.10.048